Acriflavine: How to Use Acriflavine in Fish

Acriflavine for Koi Diseases 

Acriflavine in its powder form

Acriflavine is sold in powder form and will stain the hell out of you.

Acriflavine – by Doc Johnson
General Information
Acriflavine is effective against external parasitic infections in freshwater and marine tropical ornamental fishes. As a fungicide, it is effective against Saproglenia ssp; as protozoacide, it is effective against Ambiphyra, Chilodonella, Cryptocaryon Irritans, Hexamita, Ichthyophthirius multifilis, Oodinium and Schyphidia species.
Directions for Use
Long Duration Bath (3 – 5 days) – One application of 200 milligrams of acriflavine per 10 gallons (5 ppm) of either aquarium water, static holding tank water, or shipping water. No water change is required. This will kill your plants and negatively impact your filtration system’s beneficial nitrogen reducing bacteria.
Short Duration Bath (2 hours) – Using an independent, separate treatment container with

Acriflavine dip

Acriflavine dips can be effective against many parasites and lymphocystis

appropriate aeration, prepare as 10 part per million (ppm) treatment bath. Note: 10 ppm is equivalent to 10 milligrams of acriflavine per liter of treatment water or 37.8 mg per gallon of treatmet water. After 2 hours of treatment, return fish to habitat water.
Warning: This product is intended for use solely on non-edible fish. Keep out of reach of children.
The above drug is not sold in US and for export only and for ornamental fish use only.

Doc Johnson: “More work is needed on Acriflavine. We need to establish the effect on filter bacteria, most of the common pond fish and the actual kill list among the parasites of Koi and Goldfish. Does it kill Orfe and snails? It *does* cause plants to die with amazing rapidity.”

Further: Acriflavine MSDS Sheet

Acriflavine’s MSDS Sheet 
Acriflavine MSDS – by MSDS Dept
Acriflavine MSDS

Section I – IDENTIFICATION
PRODUCT: Acriflavine Neutral
SYNONYMS: Euflavine, Trypaflavine Neutral, Neutroflavine, mixture of 3,6-diamino-10-methylacridinium chloride and 3,6-diaminoacridine
CHEMICAL ABSTRACT NO.: 8048-52-0
PRODUCT CODE NO.: 10075

Section III – HEALTH & FIRST AID INFORMATION
INHALATION: Assumed harmful. Irritant. Remove patient from exposure. If irritation persists, seek medical advice.
INGESTION: Assumed harmful. Irritant. Wash out mouth with water. Seek medical attention immediately
EYE CONTACT: Irritates and stains. Rinse eyes with plenty of water for at least 15 minutes. Seek medical attention.
SKIN CONTACT: Stains, may irritate. Hypersensitivity may occur. Wash with plenty of soap and water. Seek medical attention if irritation persists.
OTHER HEALTH INFORMATION:
LDLO = 1500 mg/kg (ivn, human)
LD SC = 250 mg/kg (mice)
To the best of our knowledge, the toxicological properties of acriflavine neutral have not been thoroughly investigated.
Section IV – PHYSICAL DATA
MELTING POINT: n.av.
SOLUBILITY IN WATER: Soluble at 330 grams/litre.
APPEARANCE AND ODOUR: Deep reddish brown or orange granualr crystalline powder
Section V – FIRE AND EXPLOSION HAZARDS
SPECIAL FIRE FIGHTING PROCEDURES & PRECAUTIONS: Wear self-contained breathing apparatus and protective clothing to prevent skin and eye contact. Use water, foam or carbon dioxide as extinquishing media.
UNUSUAL FIRE & EXPLOSION HAZARDS: Emits toxic fumes of CO, CO2, NOx, and HCl.
Section VI – REACTIVITY
STABILITY: Stable
HAZARDOUS POLYMERIZATION: Will not occur
CONDITIONS & MATERIALS TO AVOID: none
HAZARDOUS DECOMPOSITION PRODUCTS: Toxic fumes of CO, CO2, NOx, SOx and HCl.
Section VII – EMPLOYEE PROTECTION
CONTROL MEASURES: Use in a well ventilated area.
RESPIRATORY PROTECTION: Wear dust mask or self-contained breathing apparatus.
PROTECTIVE CLOTHING: Wear resistant gloves.
EYE PROTECTION: Use chemical safety goggles.
Section VIII – ENVIRONMENTAL PROTECTION
SPILL OR LEAK PRECAUTIONS: Wear respirator and gloves. Sweep or scoop spill into a salvage container and hold for disposal. Wash spill area with plenty of soap and water to remove residue.
WASTE DISPOSAL: Consult a professional disposal service.
Section IX – REGULATORY CONTROLS
DEPT. OF TRANSPORTATION: Not regulated under the Transport of Dangerous Goods Act.
DOT CLASSIFICATION: n. ap.
DOT PROPER SHIPPING NAME: n. ap.
OTHER DOT INFORMATION: n. ap.
WHMIS CLASSIFICATION: D2B
OTHER REGULATORY REQUIREMENT: n. av.
Section X – PRECAUTIONS: HANDLING, STORAGE & USAGE
Store in a cool place away from direct sunlight and high humidity.
PREPARED BY: MSDS Dept. DATE: Update March 30, 1999

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